Impact of minocycline, polymyxin B, meropenem, and amikacin on growth-prevention of Acinetobacter baumannii with various biofilm-forming capabilities
نویسندگان
چکیده
800. Improving Definitive Therapy Among Patients with Methicillin-resistant Staphylococcus aureus Bloodstream Infections: Predictors of Early Therapeutic Switch to Linezolid or Daptomycin Marin Schweizer, PhD; Kelly Richardson, PhD; Mary Vaughan Sarrazin, PhD; Michael Jones, PhD; Daniel Livorsi, MD, MSc; Rajeshwari Nair, MBBS, PhD; Michihiko Goto, MD, MSCI; Bruce Alexander, PharmD; Brice Beck, MA and Eli Perencevich, MD, MS, FIDSA, FSHEA; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, Iowa City VA Health Care System, Iowa City, Iowa, Iowa City VA Medical Center, Iowa City, Iowa, University of Iowa, Iowa City, Iowa, Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
منابع مشابه
In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy.
Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.
متن کاملPhenotypical Evaluation of Multi-Drug Resistant Acinetobacter Baumannii
Background & Objective: Resistance patterns among nosocomial bacterial pathogens in hospitals may vary widely from country to country at any given point and within the same country over time. Acinetobacter baumannii is one of the most important bacteria that cause hospital-acquired infections. Therefore, surveillance of the antibiotic resistance of Acinetobacter baumannii is necessary, especial...
متن کاملIn vitro and in vivo analysis of antimicrobial agents alone and in combination against multi-drug resistant Acinetobacter baumannii
OBJECTIVE To investigate the in vitro and in vivo antibacterial activities of tigecycline and other 13 common antimicrobial agents, alone or in combination, against multi-drug resistant Acinetobacter baumannii. METHODS An in vitro susceptibility test of 101 A. baumannii was used to detect minimal inhibitory concentrations (MICs). A mouse lung infection model of multi-drug resistant A. baumann...
متن کاملIdentification of different species of Acinetobacter Strains, and determination of their antibiotic resistance pattern and MIC of Carbapenems by E-Test
Introduction: The Gram-negative emerged an important nosocomial pathogen, especially in intensive care units. These bacteria are cause of health infections, specifically in intensive care units (ICUs). Recent reports present an increase in acinetobacters resistance to carbapenems. This study set out to determine the antibiotic resistance pattern and minimum inhibitory concentration (MIC) of car...
متن کاملAssessment of minocycline and polymyxin B combination against Acinetobacter baumannii.
Antimicrobial resistance among Acinetobacter baumannii is increasing worldwide, often necessitating combination therapy. The clinical utility of using minocycline with polymyxin B is not well established. In this study, we investigated the activity of minocycline and polymyxin B against 1 laboratory isolate and 3 clinical isolates of A. baumannii. Minocycline susceptibility testing was performe...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017